Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement
Date
2019
Authors
Gritton, Howard J.
Howe, William M.
Romano, Michael F.
DiFeliceantonio, Alexandra G.
Kramer, Mark A.
Saligrama, Venkatesh
Bucklin, Mark E.
Zemel, Dana
Han, Xue
Version
Accepted manuscript
OA Version
Citation
Howard J Gritton, William M Howe, Michael F Romano, Alexandra G DiFeliceantonio, Mark A Kramer, Venkatesh Saligrama, Mark E Bucklin, Dana Zemel, Xue Han. 2019. "Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement." Nature neuroscience, Volume 22, pp. 586 - 597.
Abstract
Striatal pavalbumin (PV) and cholinergic (CHI) interneurons are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells has made it difficult to directly assess their contribution to activity in networks of MSNs during behavior. Here, we build upon recent improvements in single cell calcium imaging combined with optogenetics to test the capacity of PVs and CHIs to affect MSN activity and behavior in mice engaged in voluntarily locomotion. We find that PVs and CHIs have unique effects on MSN activity and dissociable roles in supporting movement. PV cells facilitate movement by refining the activation of MSN networks responsible for movement execution. CHIs, in contrast, synchronize activity within MSN networks to signal the end of a movement bout. These results provide new insights into the striatal network activity that supports movement.
Description
Published in final edited form as: Nat Neurosci. 2019 April ; 22(4): 586–597. doi:10.1038/s41593-019-0341-3.