Biology
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URI: http://hdl.handle.net/2144/969
Biology at Boston University is a highly integrative department, with faculty teaching and conducting research in the broad range of fields that comprise the contemporary life sciences. The department spans the full spectrum of biological sciences, ranging from cell and molecular biology to ecology and conservation biology, giving us unusual strength in integrative research that addresses questions across multiple levels of biological complexity.
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Department chair: Kim McCall
Campus address: 5 Cummington Street, Room 101
Phone: 617-353-2432
Fax: 617-353-6340
Website: www.bu.edu/biology
All materials in OpenBU are subject to Title 17 of the U.S. Code.
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Global landscape of mouse and human cytokine transcriptional regulation
(Oxford Univ Press, 2018-10-12)Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription ... -
Identification of single nucleotide non-coding driver mutations in cancer
(Frontiers Media SA, 2018-02-02)Recent whole-genome sequencing studies have identified millions of somatic variants present in tumor samples. Most of these variants reside in non-coding regions of the genome potentially affecting transcriptional and ... -
Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters
(Oxford University Press, 2013)Gene expression is controlled through the binding of transcription factors (TFs) to regulatory genomic regions. First introns are longer than other introns in multiple eukaryotic species and are under selective constraint. ... -
Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities
(eLife Sciences Publications Limited, 2015-04-23)Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a compact genome and a wealth of genomic tools. However, identification of regulatory elements has been limited, as DNA-binding motifs ... -
A gene‐centered C. elegans protein–DNA interaction network provides a framework for functional predictions
(EMBO Press, 2016-10-24)Transcription factors (TFs) play a central role in controlling spatiotemporal gene expression and the response to environmental cues. A comprehensive understanding of gene regulation requires integrating physical protein–DNA ... -
CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
(Cold Spring Harbor Laboratory, 2018-10-23)The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling. Transcription of the NEMO gene ... -
Resilience of Atlantic slippersnail Crepidula fornicata larvae in the face of severe coastal acidification
(Frontiers Media SA, 2018-08-30)Globally, average oceanic pH is dropping, and it will continue to decline into the foreseeable future. This ocean acidification (OA) will exacerbate the natural fluctuations in pH that nearshore ecosystems currently ... -
De novo transcriptome assembly of the clown anemonefish (Amphiprion percula): a new resource to study the evolution of fish color
A fundamental question of evolutionary biology is, why are some animals conspicuously colored? This question may be addressed from both a proximate (genetic and ontogenetic) and ultimate (adaptive value and evolutionary ... -
Na(V)1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons
(AMER PHYSIOLOGICAL SOC, 2014-09-01)Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both forms of firing are physiologically important. We studied voltage-gated Na+ channels in OSNs to assess their role in spontaneous ... -
Optogenetic activation of accessory olfactory bulb input to the forebrain differentially modulates investigation of opposite versus same-sex urinary chemosignals and stimulates mating in male mice
(2017-03)Surgical or genetic disruption of vomeronasal organ (VNO)-accessory olfactory bulb (AOB) function previously eliminated the ability of male mice to processes pheromones that elicit territorial behavior and aggression. By ...
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