Biology
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URI: http://hdl.handle.net/2144/969
Biology at Boston University is a highly integrative department, with faculty teaching and conducting research in the broad range of fields that comprise the contemporary life sciences. The department spans the full spectrum of biological sciences, ranging from cell and molecular biology to ecology and conservation biology, giving us unusual strength in integrative research that addresses questions across multiple levels of biological complexity.
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Department chair: Kim McCall
Campus address: 5 Cummington Street, Room 101
Phone: 617-353-2432
Fax: 617-353-6340
Website: www.bu.edu/biology
All materials in OpenBU are subject to Title 17 of the U.S. Code.
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Enhanced yeast one-hybrid screens to identify transcription factor binding to human DNA sequences
(Journal of Visualized Experiments, 2019-02-11)Identifying the sets of transcription factors (TFs) that regulate each human gene is a daunting task that requires integrating numerous experimental and computational approaches. One such method is the yeast one-hybrid ... -
Uncovering human transcription factor interactions associated with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays
(2018-11-01)Identifying transcription factor (TF) binding to noncoding variants, uncharacterized DNA motifs, and repetitive genomic elements has been difficult due to technical and computational challenges. Indeed, current experimental ... -
Global landscape of mouse and human cytokine transcriptional regulation
(Oxford Univ Press, 2018-10-12)Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription ... -
Identification of single nucleotide non-coding driver mutations in cancer
(Frontiers Media SA, 2018-02-02)Recent whole-genome sequencing studies have identified millions of somatic variants present in tumor samples. Most of these variants reside in non-coding regions of the genome potentially affecting transcriptional and ... -
Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities
(eLife Sciences Publications Limited, 2015-04-23)Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a compact genome and a wealth of genomic tools. However, identification of regulatory elements has been limited, as DNA-binding motifs ... -
A gene‐centered C. elegans protein–DNA interaction network provides a framework for functional predictions
(EMBO Press, 2016-10-24)Transcription factors (TFs) play a central role in controlling spatiotemporal gene expression and the response to environmental cues. A comprehensive understanding of gene regulation requires integrating physical protein–DNA ... -
Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters
(Oxford University Press, 2013)Gene expression is controlled through the binding of transcription factors (TFs) to regulatory genomic regions. First introns are longer than other introns in multiple eukaryotic species and are under selective constraint. ... -
CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
(Cold Spring Harbor Laboratory, 2018-10-23)The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling. Transcription of the NEMO gene ... -
De novo transcriptome assembly of the clown anemonefish (Amphiprion percula): a new resource to study the evolution of fish color
A fundamental question of evolutionary biology is, why are some animals conspicuously colored? This question may be addressed from both a proximate (genetic and ontogenetic) and ultimate (adaptive value and evolutionary ... -
Resilience of Atlantic slippersnail Crepidula fornicata larvae in the face of severe coastal acidification
(Frontiers Media SA, 2018-08-30)Globally, average oceanic pH is dropping, and it will continue to decline into the foreseeable future. This ocean acidification (OA) will exacerbate the natural fluctuations in pH that nearshore ecosystems currently ...
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