Mapping cerebral blood flow with speckle contrast optical spectroscopy
OA Version
Citation
Abstract
Cerebral blood flow (CBF) is a critical component of cerebral hemodynamics, yet the existing optical neuroimaging modalities to measure CBF do not have sufficient signal-to-noise ratio. Speckle contrast optical spectroscopy (SCOS) has been previously considered as an alternative approach to use near-infrared light to measure CBF non-invasively in humans. Several advancements in use of SCOS for CBF measurement are presented here. A data processing pipeline considering various noise sources and a pulsed laser setup were developed to account for the low photon flux at the source detector separations necessary in human CBF measurement. A camera characterization pipeline optimized for SCOS was developed to expand the range of cameras available. By choosing scalable source and detector systems, a high density, multi-channel SCOS system was developed, allowing for mapping of CBF changes during cognitive task induced cerebral activity. With these three advancements, non-invasively monitoring CBF changes in humans with high spatial and temporal resolution becomes possible.
Description
2027
License
Attribution 4.0 International