The association between periodontal disease and stroke in the elderly
Date
2004
DOI
Authors
Lee, Hyo-Jung
Version
OA Version
Citation
Abstract
Since the late 1980's, several studies have been conducted to investigate the relationship between periodontal disease and ischemic stroke. The purpose of this study is to investigate the relationship of periodontal disease to self-reported history of stroke in the elderly (60 years of age and older) with a special emphasis on elderly women. Data from the Third National Health and Nutrition Examination Survey (NHANES III), a large population-based cross-sectional survey of the United States, were utilized for this study. Since we have 1,563 edentulous subjects from a total of 5,123 subjects and periodontal disease is a major cause of tooth loss, it was necessary to account for this in our statistical analysis. Hence, we developed a new index called the Periodontal Health Status (PHS) index. The results showed that the percent of sites with at least 2 mm of attachment loss and percent of sites with at least 3 mm of attachment loss were significantly related to stroke history in unadjusted models (p=0.003, p=0.001, respectively). When we fit the multiple logistic regression model for attachment loss with all possible potential confounders, the association of the percent of sites with at least 2 mm of attachment loss to history of stroke and the association of the percent of sites with at least 3 mm of attachment loss to history of stroke were only marginally significant (p=0.045, p=0.060, respectively). In the logistic regression models with stratification by gender, males did not show statistically significant relationship between Periodontal Health Status (PHS) and stroke history. In contrast, females showed some marginal association between Periodontal Health Status (PHS) and stroke history. Further longitudinal intervention studies need to be conducted to determine the temporal relationship between periodontal disease and stroke.
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Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontics).
Includes bibliographical references (leaves 78-84).
Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontics).
Includes bibliographical references (leaves 78-84).
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This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.