Associated risk factors and rate of relapse of plaque psoriasis following withdrawal of biologics
OA Version
Citation
Abstract
Psoriasis is a chronic skin disease treated by a host of options. The most efficient treatments available are the biologic agents, that once initiated are often continued until further notice as discontinuation will likely lead to relapse. Many patients face withdrawal from these agents, reasons being multifactorial, and the risk of relapse often continues to increase the further one gets from withdrawal. There are a multitude of risk factors associated with faster times to relapse and protective factors, specifically lifestyle factors and serum levels of inflammatory cytokines. There are also small cohorts in nearly all studies of time to relapse that do not relapse at all. The goal of this proposal is to study both inflammatory cytokine levels and lifestyle habits in non-relapsers in real-world practice. This data may be used clinically to help prevent relapse in others or potentially highlight further evidence in the psoriasis pathway that may help with treatment advancement.
Description
2024