Exploration of diagnostic methods and novel treatments for inflammatory breast cancer: a review to raise awareness and improve diagnosis and prognosis
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Abstract
Inflammatory breast cancer (IBC) poses a significant challenge in breast cancer management because of its aggressive nature and propensity for delayed diagnosis. This literature-based thesis investigated the current landscape of diagnostic methods and novel treatments for IBC with the aim of raising awareness and enhancing diagnosis and prognosis. Through an extensive review of existing literature and empirical evidence, this thesis delved into the clinical presentation, diagnostic modalities, prognostic factors, and treatment strategies specific to IBC. Key diagnostic methods, including imaging modalities (e.g., mammography, ultrasound, magnetic resonance imaging) and molecular diagnostics (e.g., biomarkers, gene expression profiling), were examined in detail and highlighted for their utility in early detection and characterization of IBC. Moreover, novel treatment approaches, such as targeted therapies (e.g., HER2 inhibitors, hormone therapy), immunotherapy, and emerging molecularly targeted agents, were explored for their potential to improve outcomes in IBC patients. The resulting discussion encompassed the barriers to early diagnosis and treatment initiation and emphasized the importance of both prompt recognition of IBC symptoms and multidisciplinary management. Future directions for personalized medicine and precision oncology in IBC are elucidated, underscoring the need for continued research into biomarkers, therapeutic targets, and innovative treatment modalities. By shedding light on the complexities of IBC diagnosis and treatment, this thesis can contribute to ongoing efforts to raise awareness, improve clinical outcomes, and ultimately reduce the burden of IBC on patients and healthcare systems.
Description
2024