Polymorphisms of FSHR, ESR and CYP19A1 and ovarian stimulation outcome
Embargo Date
Indefinite
OA Version
Citation
Abstract
Ovarian stimulation is frequently used in many assisted reproductive technologies (ART)
procedures to increase the number of dominant follicles. However, achieving the optimal
response to ovarian stimulation without complications can be difficult. In our study, we predict that future ovarian stimulation procedures will be more individually catered to each patient. A study that established a predictor model for ovarian stimulation showed that genetic single nucleotide polymorphisms (SNP) are good predictive factors (Fauser et al., 2007). Thus the objective of this study was to determine if there was any association between the various parameters that measure the success of ovarian stimulation and FSHR, CYP19, ESRJ and ESR2 singe nucleotide polymorphisms (SNP). A total of two hundred and four women undergoing either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were genotyped to study the distribution of the different SNPs. Complete clinical information was available for a range of forty nine to seventy three women to study any association between genotype and basal FSH level (day 3), basal 17 -beta estradiol level, number of follicles, number of eggs and the level of 17-beta estradiol during hCG administration. The association was studied using the one way ANOVA test and linear regression model. There was a significant correlation between the CYP 19Al rs10046 genotypes and FSH level (p=0.004), number of follicles (p=0.03) and level of 17-beta estradiol during hCG administration (p=0.04). Also, FSHR rs2268263 genotype was significantly linked to FSH level between the G-allele group (A/G and G/G) and the homozygote A group (p=0.04). Taken all together, these results suggest that several genes-especially CYP 19AJ and FSHR rs2269263- play a significant role in determining the success of ovarian stimulation.
Description
Thesis (M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.