Oxidation of progesterone and related compounds with hydrogen peroxide under various conditions
OA Version
Citation
Abstract
Oxygenated derivatives of progesterone have been isolated from animal tissue such as adrenal glands. The oxygen, either as hydroxyl or a carbonyl, has been found at carbons 6, 11, 17, 18, 19 and 21. These oxygenated derivatives are of biological significance particularly if the or, b-unsaturated carbonyl system in ring A is retained. Many such substances can be obtained by subjecting progesterone to oxidation in biochemical systems, e.g., perfusion through the intact adrenal gland, incubation with gland preparations and fermentation by microbes. The exact courses of these oxidations are unknown.
The object of this research was to see if oxygen could be directly introduced into the complex progesterone molecule, with retention of the ring A or, b-saturated carbonyl system, through the interaction of the substance with activated hydroxyl radicals produced by dissociation of hydrogen peroxide with ultraviolet light [TRUNCATED]
Description
Thesis (Ph.D.)--Boston University
License
Based on investigation of the BU Libraries' staff, this work is free of known copyright restrictions.