Mapping the binding of protein heterodimers containing human transcription factors and viral transcription regulators to promoters of immune response genes and cancer genes
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Abstract
Viruses are infectious disease- and cancer-causing agents. Viral infection in humans leads to a variety of cytopathic effects. Viral transcription regulators (vTRs) play a central role in human biological processes by modulating host gene expression through direct and indirect methods of binding to nucleic acids making it important to study. Despite the important role of vTRs in human disease, our understanding of their molecular features and functions remains limited. The focus of this study looks at vTR and human transcription factor (hTF) pairs in order to determine how vTRs affect the binding of hTFs to cytokine and cancer gene promoters. In this study we are conducting a pY1H screen using 139 vTR-hTF pairs, 83 cancer promoters, and 41 cytokine promoters. A total of 108 interactions were seen with results highlighting information about viral genome, family, and species. Overall, this study has offered a revolutionary method to study hTFs and vTRs as pairs in a variety of immune and cancer gene promoters to understand more about mechanisms of host gene regulation.
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Attribution 4.0 International