Associations between serum lipids and cerebral amyloid angiopathy in longitudinal studies of aging
Embargo Date
2027-10-27
OA Version
Citation
Abstract
BACKGROUND: Cerebral amyloid angiopathy (CAA) is a common age-related vascular disorder associated with cognitive decline and dementia. The relationship between CAA and serum lipid levels in aging is minimally investigated. Thus, we investigated the association of CAA with serum lipid levels in two longitudinal studies of aging.
OBJECTIVE: To elucidate the relationship between serum lipid levels and the presence of moderate to severe CAA in older adults.
METHODS: A retrospective cohort analysis was conducted utilizing medical records from the Rush Alzheimer’s Disease Center. The study comprised 1,964 participants from the Rush Memory and Aging Project and the Religious Orders Study. Serum lipid levels, including total cholesterol, LDL, HDL, HDL ratio, and triglycerides, were examined. CAA presence and severity were categorized based on postmortem neuropathological assessment. Multiple regression models were used to analyze the association of serum lipids with moderate or severe CAA controlling for demographic factors.
RESULTS: Among 1,964 participants, 722 had moderate or severe CAA, while 1,205 had no or mild CAA. After controlling for fasting status, body mass index, apolipoprotein E allele, and demographical factors, triglyceride was associated with higher odds of moderate or severe CAA (odds ratio (OR), 1.0045 [95% CI, 1.0016–1.0073), while HDL cholesterol was associated with lower odds of moderate or severe CAA (OR, 0.9879 [95% CI, 0.9783–0.9975]).
CONCLUSION: This study reveals associations between triglyceride and HDL levels with presence of moderate to severe CAA. Further research is needed to better understand the associations and potential roles of these lipids in pathogenesis of CAA.
Description
2024