Increased resolution: application of single-cell transcriptomic methods in cancer research
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Abstract
The adoption of single-cell transcriptomic research methods has brought forth a new stage in cancer research. The increased cellular resolution granted by these methods over that of bulk transcriptomic methods has allowed researchers to implement new strategies to study cancer biology and oncological therapeutic approaches. From examining tumor microenvironments to verifying robust immune responses in response to cancer vaccination, single-cell transcriptomic methods and their relevant analysis pipelines have proven that they can reliably generate accurate transcriptional data while providing the framework for additional forms of analysis that bulk transcriptomic approaches cannot offer. Improvements and advancements in this field, like the introduction of single-cell spatial transcriptomics, will ensure that single-cell transcriptomics will continue to be heavily implicated in future advancements in cancer research and therapy.