Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers
Files
First author draft
Date
2021-05-04
Authors
Jayne, Rachael K.
Karakan, M. Çağatay
Zhang, Kehan
Pierce, Noelle
Michas, Christos
Bishop, David J.
Chen, Christopher S.
Ekinci, Kamil L.
White, Alice E.
Version
First author draft
OA Version
Citation
R.K. Jayne, M.Ç. Karakan, K. Zhang, N. Pierce, C. Michas, D.J. Bishop, C.S. Chen, K.L. Ekinci, A.E. White. 2021. "Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers." Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering, Volume 21, Issue 9, pp.1724-1737. https://doi.org/10.1039/d0lc01078b
Abstract
We have developed a microfluidic platform for engineering cardiac microtissues in highly-controlled microenvironments. The platform is fabricated using direct laser writing (DLW) lithography and soft lithography, and contains four separate devices. Each individual device houses a cardiac microtissue and is equipped with an integrated strain actuator and a force sensor. Application of external pressure waves to the platform results in controllable time-dependent forces on the microtissues. Conversely, oscillatory forces generated by the microtissues are transduced into measurable electrical outputs. We demonstrate the capabilities of this platform by studying the response of cardiac microtissues derived from human induced pluripotent stem cells (hiPSC) under prescribed mechanical loading and pacing. This platform will be used for fundamental studies and drug screening on cardiac microtissues.