L-triiodothyronine induced hyperthyroidism in the guinea pig: a study of its effects on the periodontium
Date
1970
DOI
Authors
Hannigan, Edward J.
Version
OA Version
Citation
Abstract
Young adult guinea pigs were made hyperthyroid over a period of five weeks by daily injection of 3, 5, 31 triiodothyronine. To prevent the possibility of
concomitant scorbutic changes during this period, the animals were kept on an
ascorbic acid free diet and a daily injection of ascorbic acid allowed known adequate
supplementation. Animals were sacrificed weekly for histology, first having
perfused the microcirculation with Gunther-Wagner Biologica I ink. A documentation
of the changes in the periodontium of the continually erupting mandibular
incisor with spec ia I note of changes in the periodontal ligament microcirculation
was pursued. Concomitant changes in the endochondral bone formation in the long
bones was documented.
In the periodontium, osteoblastic and odontoblastic integrity were not
interfered with, possibly due to the prevention of scorbutic changes. In the later
stages of the project, an osteoporosis of supporting bone of the periodontium, an
increased resorptive activity of alveolar bone, a lesser collagenation of the periodontal
ligament on the alveolar side, a vasodilation and leakage of the carbonsuspension
perfusion from the ligament vessels were constant findings.
Cessation of endochondral bone formation of the epiphyseal plate. of the
humerus was evident as early as two weeks into the study.
Description
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Thesis (M.Sc.D.)--Boston University, School of Graduate Dentistry. Dept. of Periodontology, 1970.
Bibliography included.
Thesis (M.Sc.D.)--Boston University, School of Graduate Dentistry. Dept. of Periodontology, 1970.
Bibliography included.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.