Identification of mTOR interaction partners in the nucleus
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Citation
Abstract
Embryonic diapause is a vital reproductive strategy that allows the continuing fitness of various species in response to stressful conditions. The blastocyst can remain in this paused state for an extensive duration while remaining pluripotent. This diapaused state can be recapitulated by inhibiting mTOR, a central regulator of cellular growth. This classically cytoplasmic protein was found to have nuclear function in regard to the epigenetic landscape. However, the mechanism of how mTOR enters the nucleus or binds to DNA is not well understood. This thesis attempts to identify the potential interactors of nuclear mTOR in its role in pluripotency maintenance.
Description
2024