Effect of scaling and root planning with topical doxycycline vs scaling and root planning alone on the subgingival microbiota of chronic periodontitis patients
Date
2003
DOI
Authors
Abdullah, Yaqoub
Version
OA Version
Citation
Abstract
The objective of the present investigation was to compare the effect of topical application of Doxycycline 10% (Atridox™) following scaling and root planning versus scaling and root planning alone on the subgingival plaque composition of patients with generalized severe chronic periodontitis. 7 patients (4 males, 3 females) with generalized severe chronic periodontitis were selected from the patient population at Boston University. Using a split mouth design, one side of the mouth received scaling and root planning under local anesthesia followed by an application of topical Doxycycline while the other side (control) was treated with scaling and root planning alone. Subgingival plaque samples were taken at baseline and 2 months after treatment. Microbiological analysis was carried out using checkerboard DNA probe technology. Plaque samples were screened for the presence of Actinomyces naeslundii, Tanerella forsythensis (ex Bacteroide sforsythus), Campylobacter conscisus, Campylobacter curva, Campylobacter rectus, Capnocytophaga sputigena, Eikenella corrodens, Fusobacterium nucleatum ss vincentii, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigricens, Streptococcus oralis, Treponema denticola, Actinobacillus actinomycetemcomitans serotype b. Two months post treatment there was a significant decrease in total bacterial counts in both groups. There was a statistically significant difference between the 2 groups (test and control), post treatment, with regards to bacterial composition. Pathogens such as Tanerella forsythensis, Porphyromonas gingivalis and Treponema denticola were reduced significantly when Atridox was used in addition to scaling and root planning, while Actimomyces viscosus and Streptococcus oralis levels were increased. The topical application of Doxycycline 10% as an adjunct to scaling and root planning is beneficial to the non surgical management of patients with generalized severe chronic periodontitis.
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Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2003 (Oral Biology).
Includes bibliography: leaves 31-40.
Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2003 (Oral Biology).
Includes bibliography: leaves 31-40.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.