Opsonization of Porphyromonas gingivalis with specific IgG prevents P gingivalis-induced oral bone loss
Date
2004
DOI
Authors
Wong, Hoi Sze Jodie
Version
OA Version
Citation
Abstract
Generalized Aggressive Periodontal disease (GAP) is a chronic inflammatory disease of the periodontium that is elicited by microbial infection. Porphyromonas gingivalis, believed to be the etiological agent of GAP, produces a variety of virulence factors that enable this organism to stimulate disease. Previous studies have documented that immunization with P. gingivalis or relevant antibody isolated from this organism prevents subsequent P. gingivalis infection; however, the mechanism of protection is poorly defined. In this study, we determined if mice given opsonized antibody to P. gingivalis prior to oral challenge afforded protection from P. gingivalis elicited oral bone loss using a murine model. Balb/c mice were gavaged with P. gingivalis A7436 opsonized with P. gingivalis A7436-specific IgG (Pg-IgG), or irrelevant mouse IgG (IRR)-IgG or received no treatment. Mice orally challenged with Pg A7436 opsonized with whole organism specific IgG possessed significantly less oral bone loss as compared with animals challenged with irrelevant IgG (IRR)-IgG treated Pg and mice challenged with untreated Pg A7436. These data suggest that opsonization with specific IgG raised against P. gingivalis can protect mice from oral bone loss.
Description
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Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontics).
Includes bibliographical references (leaves 41-49).
Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004 (Periodontics).
Includes bibliographical references (leaves 41-49).
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.