The comorbidity of substance use and traumatic brain injury: a comprehensive review on the prevalence, psychosocial correlates, and clinical implications

Date
2025
DOI
Version
OA Version
Citation
Abstract
Traumatic brain injury (TBI) and substance use disorders (SUDs) frequently co-occur, posing a complex challenge in treatment and long-term management. Extensive research has demonstrated that substance use increases the risk of TBI, while other studies have shown that TBI can exacerbate susceptibility to substance misuse. However, there is limited understanding of the psychosocial correlates faced by individuals with co-occurring TBI and SUD. Some studies have recognized that psychological and behavioral correlates, such as mood disorders and impaired social functioning, are prevalent in individuals with TBI. These correlates not only impact daily life but also hinder treatment and rehabilitation. Therefore, diagnostic challenges arise due to overlapping symptoms between TBI and substance use effects, necessitating improved screening tools and assessments. Drawing upon a comprehensive review of current literature, approaches to modify psychosocial treatments to accommodate better the unique challenges faced by individuals with TBI and SUD were examined. It was found that psychological and social identity changes influence a person’s experience after sustaining a TBI. For clinicians to develop effective treatment plans, it is essential to understand the individual’s life circumstances before and after the injury. Incorporating positive behavioral therapy to reshape self-identity, as well as opportunities to strengthen personal relationships, can enhance psychosocial well-being and guide clinical interventions for individuals with a history of TBI and SUD. Future research should prioritize longitudinal studies to explore TBI and SUD interventions that address the challenges associated with psychosocial factors.
Description
2025
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