Studies concerning the histotoxic and neoplastic potential of isobutyl-2-cyanoacrylate and analysis of its effect on sequential wound healing when employed as an oral hemostat in the Long-Evans rat
Date
1974
DOI
Authors
Greer, Robert O.
Version
OA Version
Citation
Abstract
An experimental study was implemented to determine the
effectiveness of isobutyl-2-cyanoacrylate (bucrylate) as an
oral hemostat, its influence on sequential wound healing
and its potential as a carcinogen.
Segregated groups of equa] numbers of male and female
Long-Evans Hooded Rats underwent deep (socket) and superficial
(surface) aerosol placement of bucrylate to maxillary molar extraction sites.
Bucrylate proved to be an effective oral hemostat,
rapidly retarding postextraction hemorrhage. Deep placement
of the adhesive resulted in retarded healing and
lingering macrohistiocytic aggregates in wounds. Superficial
placement of the material resulted in very little long term
macrohistioeytic response and wound healing showed little
retardation. A neoplastic potential was not demonstrated
for bucrylate.
Description
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Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry, 1974. Oral pathology.
Bibliography included.
Thesis (D.Sc.D.)--Boston University School of Graduate Dentistry, 1974. Oral pathology.
Bibliography included.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.