Identifications of gluten-degrading bacteria in human fecal samples
Date
2013
DOI
Authors
Valery Lara, Adriana Carolina
Version
OA Version
Citation
Abstract
Celiac Disease (CD) is a chronic inflammatory and autoimmune disorder of
the small intestine characterized by an aberrant immune response to gluten proteins
(primarily gliadins). Gluten are found in wheat, barley and rye and cause CD in
genetically predisposed individuals. The genetic predisposition is given by the
presence of either HLA-DQ2 or HLA-DQ8 genes in CD patients. Autoantibodies to
tissue transglutaminase (TG2) and gluten are present as a consequence of the
activation of the adaptive immune system. CD presents clinically with diarrhea and
intestinal discomfort due to villous atrophy and may lead to anemia, osteoporosis
and lymphomas.
All signs and symptoms of celiac disease are triggered by the ingestion of
gluten. Thus, the treatment of CD consists of strict exclusion of gluten from the diet,
being the only treatment option currently available. The diet is very difficult to comply
with, and gluten contamination in foods is a major problem for the CD patient ... [TRUNCATED]
Description
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2013 (Department of Molecular and Cell Biology).
Includes bibliography: leaves 52-59.
Includes bibliography: leaves 52-59.
License
This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.