Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion
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First author draft
Date
2024-10-29
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First author draft
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Citation
M. Howe, B. Fearey. 2024. "Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion" bioRxiv. https://doi.org/10.1101/2024.10.29.620847
Abstract
Locomotion is continuously regulated by an animal’s position within an environment relative to goals. Direct and indirect pathway striatal output neurons (dSPNs and iSPNs) influence locomotion, but how their activity is naturally coordinated by changing environments is unknown. We found, in head-fixed mice, that the relative balance of dSPN and iSPN activity was dynamically modulated with respect to position within a visually-guided locomotor trajectory to retrieve reward. Imbalances were present within ensembles of position-tuned SPNs which were sensitive to the visual environment. Our results suggest a model in which competitive imbalances in striatal output are created by learned associations with sensory input to shape context dependent locomotion.
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The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International.