Sensory neurons in adipose tissue control the renewal of naïve progenitor cells
Embargo Date
2027-11-16
OA Version
Citation
Abstract
Obesity, a condition marked by excessive body fat, leads to various health issues such as metabolic disorders, cardiovascular diseases, and certain cancers. The role of adipose tissue (AT) is crucial to comprehending obesity. While BAT is known for its role in thermogenesis-based energy disposal, WAT is primarily engaged in energy storage. In metabolic studies, the transformation of WAT into beige adipocytes—which display characteristics of BAT—has drawn a lot of attention. The basic mechanisms that relate the dynamics of adipose tissue to obesity are still not fully understood, despite a great deal of research. The purpose of this thesis is to examine how sensory neurons regulate the function of AT, with a particular focus on how these neurons regulate the renewal of naïve progenitor cells.
Description
2024