The effect of diet on hypercholesterolemia in kidney transplant recipients
Date
1995
DOI
Authors
Sullivan, Susan S.
Version
OA Version
Citation
Abstract
The increased incidence of hypercholesterolemia in transplant recipients may relate to immunosuppressive medications cyclocyclosporine and prednisone among other factors. The transplant population may respond differently to diet therapy for hyperlipidemia than the general population. This study compared the effects of cholesterol-lowering diet intervention on lipid levels in hypercholesterolemic kidney transplant recipients and hypercholesterolemic normal subjects. Seven adult subjects with cholesterol levels above 240 mg/dl were recruited from the transplant clinic. To minimize complicating variables, subjects were on stable medication regimens including prednisone and cyclosporine, were at least one year after kidney transplantation, were not diabetic, had normal kidney and liver functions, and were not on lipid lowering medications. An additional seven hypercholesterolemic, non-transplant subjects were recruited from the community. The transplant and control groups underwent the same diet protocol. After baseline lipid levels (cholesterol, HDL, LDL, trig]ycerides) were determined, and baseline eating habits were assessed via four-day food records, the subjects underwent eight weeks of controlled eating. The first four weeks consisted of the average American diet ( 14% saturated fat, 37% total fat, and 400 mg cholesterol). The second four weeks consisted of the National Cholesterol Education Program’s Step-Two Diet (7% saturated fat, 30% total fat, 10% polyunsaturated fat, 200 mg cholesterol). Three lipid profiles were measured on each diet.
To improve compliance, the free-living subjects were given most of the food from the Clinical Research Center kitchen. As expected, the control subjects experienced an average decrease in total cholesterol of 35 mg/dl. The transplant subjects experienced a significantly lower decrease in total cholesterol of 14 mg/dl. Among the transplant subjects, response to the lipid-lowering diet was positively correlated with creatinine clearance and negatively correlated with blood cyclosporine levels. The effects of cyclosporine on the liver may influence LDL receptor regulation. HDL-cholesterol levels were higher in transplant subjects then in the control subjects suggesting a less atherogenic lipid profile in the transplant subjects.
Description
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Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1995 (Nutritional Sciences).
Includes bibliographical references: (leaves 88-97).
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1995 (Nutritional Sciences).
Includes bibliographical references: (leaves 88-97).
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.