Printable microscale interfaces for long-term peripheral nerve mapping and precision control
Files
First author draft
Date
2019-07-01
DOI
Authors
Otchy, Timothy
Michas, Christos
Lee, Blaire
Gopalan, Krithi
Gleick, Jeremy
Semu, Dawit
Darkwa, Louis
Holinski, Bradley J.
Chew, Daniel J.
White, Alice E.
Version
OA Version
First author draft
Citation
Timothy Otchy, et al. 2019. "Printable microscale interfaces for long-term peripheral nerve mapping and precision control." bioarxiv, https://doi.org/10.1101/688218
Abstract
The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrode-based devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device – the nanoclip – for chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints. We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.
Description
License
The copyright holder for this preprint is the author/funder. It is made available under a CC-BY 4.0 International license.