The promise of tissue engineering and regenerative medicine in the future of transplant surgery
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Abstract
Tissue engineering and regenerative medicine hold the promise of revolutionizing transplant surgery by addressing critical challenges such as organ shortages, immune rejection, and long-term immunosuppression. This thesis explores the integration of advanced biomaterials, stem cell technologies, and three-dimensional bioprinting to develop engineered tissues that closely mimic the structure and function of native organs. By leveraging induced pluripotent stem cells (iPSCs) and biodegradable scaffolds, current research efforts are paving the way for personalized regenerative therapies that can potentially replace damaged or diseased tissues.A comprehensive review of existing methodologies reveals the importance of factors such as vascularization, mechanical stability, and immune compatibility in ensuring the success of tissue-engineered constructs. Additionally, emerging trends in in-situ tissue regeneration and innovative bioreactor designs are examined to highlight strategies that overcome limitations in scalability and reproducibility. Ethical considerations and evolving regulatory frameworks are also discussed, providing context for the translation of laboratory findings into clinical applications.
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2025