PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse
Files
Accepted manuscript
Date
2005-07-01
Authors
Zhang, G. L.
Srinivasan, K. N.
Veeramani, A.
August, J. T.
Brusic, V.
Version
OA Version
Citation
G. L. Zhang, K. N. Srinivasan, A. Veeramani, J. T. August, V. Brusic. 2005. "PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse." Nucleic Acids Research, Volume 33, Issue Web Server, pp. W180 - W183.
Abstract
PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The pre- diction system utilizes quantitative matrices, which were rigorously validated using experimentally deter- mined binders and non-binders and also by in vivo studies using viral proteins. The prediction perform- ance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the pre- diction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.