Effects of naringenin, rutin, and hesperidin on experimental alveolar bone loss
Date
1988
DOI
Authors
Abitbol, Thierry E.
Version
OA Version
Citation
Abstract
Bioflavonoids are naturally occuring compounds, and thelr importance may have particular value in human nutrition.
The purpose of this study is to compare three bioflavonoids (rutin, hesperidin, and naringenin) on periodontal disease (alveolar bone loss) in the rat.
The rat has proven to be a valuable experimental animal for nutritional research. Its small size lends convenience to the study and its diet as an omnivore closely resembles that of man.
Male albino rats were fed a moderately cariogenic diet for a period of forty-two days. At the end of this period, the rats were killed, and the alveolar bone was dissected, isolated, and later examined under a dissecting microscope equipped with a reticle lens. By this technique, it was possible to determine alveolar bone loss with significant accuracy.
Alveolar bone loss from maxillary and mandibular jaws was scored at various buccal and lingual surfaces. The sites selected were mesial, midpoint, and distal surfaces of the first molars.
Results showed that alveolar bone loss was greater in the group of animals not receiving any bioflavonoid supplementation in their diet. From these observations, itis concluded that the bioflavonoids tested had a beneficial effect in preventing alveolar bone loss in the rat.
Earlier studies from this and other laboratories have reported on the influence of nutrition in periodontal health (1). The present study not only sheds light on the potential of bioflavonoids in their role in the prevention of periodontal disease; it also adds further credence to the argument that a significant nutritional lack may contribute to periodontal pathology. This would not imply that diet in itself contributes directly to periodontal bone loss but rather that a particular nutritional lack may exacerbate or initiate a pathogenic process. The implication is that dietary supplements may help prevent periodontal disease.
Consequently further research is warranted to establish the role of diet on the prevention of periodontal disease (2-4 ), and to decipher the exact mechanism by which bioflavonoids, either directly on osseous tissue or indirectly on contiguous structures, affect bone loss.
Description
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Thesis (M.S.)--Boston University, Hernry M. Goldman School of Graduate Dentistry, 1988 (Nutritional Sciences)
Bibliography : leaves 46-67.
Thesis (M.S.)--Boston University, Hernry M. Goldman School of Graduate Dentistry, 1988 (Nutritional Sciences)
Bibliography : leaves 46-67.
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This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.