Histone deacetylase 4 is a critical regulator of chondrocyte proliferation
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Abstract
Chondrocytes are vital to maintaining the structural and functional integrity of joints and cartilage. Inadequate chondrocyte cell number has been linked to the development of severe problems, including osteoarthritis. Histone deacetylase 4 (HDAC4) was identified as a potential regulator of chondrocyte proliferation. Through a gain- and loss-of function approach, we studied the effect of HDAC4 on chondrocytes in vitro. In our experimental groups we discovered that HDAC4 stimulates proliferating cell nuclear antigen protein expression, increases total cell counts, elevates the ratio of proliferating to non-proliferating cells, enhances Sox9 gene expression, and inhibits cell differentiation. Based on these findings, we propose that HDAC4 is a critical regulator of chondrocyte proliferation.
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Thesis (M.A.)--Boston University
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