Salivary biomarkers and initial dental alignment
Date
2014
DOI
Authors
Nassif, Laura
Version
OA Version
Citation
Abstract
Background: Orthodontic tooth movement is an elaborate process with multiple complex molecular and cellular involvements. The current interest in the research community is to observe specific molecules and cells involved in tissue remodeling and inflammation, and to find new non-invasive collection methods for that purpose. The aim of this study was to explore the relationship between salivary IGF-1, alkaline phosphatase, TGF-β, BMPs, testosterone and initial tooth movement during orthodontic treatment.
Methods: 15 healthy orthodontic patients (6 males, 9 females) with a mean age of 13.2 years, a non-extraction treatment plan, and at least 2 mm of crowding or spacing, were selected for this study. Alginate impressions, and 10 mL saliva samples were collected at pretreatment (T0), 4 weeks after appliance and wire placement (Tl), and at least 2 months after Tl (T2). The saliva samples were analyzed to determine the concentrations of the biomarkers selected for each time point. Little′s irregularity index was used to measure dental malalignment on the casts made from the alginate impressions taken at each time point. The null hypothesis was tested using Friedman’s test.
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Description
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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Orthodontics).
Includes bibliographic references: leaves 45-56.
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Orthodontics).
Includes bibliographic references: leaves 45-56.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.