Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
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Accepted manuscript
Date
2017-10-01
Authors
Tang, Jianbo
Erdener, Sefik Evren
Fu, Buyin
Boas, David A.
Version
OA Version
Published version
Citation
Jianbo Tang, Sefik Evren Erdener, Buyin Fu, David A Boas. 2017. "Capillary red blood cell velocimetry by phase-resolved optical coherence tomography." OPTICS LETTERS, Volume 42, Issue 19, pp. 3976 - 3979 (4). https://doi.org/10.1364/OL.42.003976
Abstract
We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift of flowing RBCs. The angular frequency of the signal from flowing RBCs was then quantified from the dynamic component of the signal and used to calculate the axial speed of flowing RBCs in capillaries. We validated our measurement by RBC passage velocimetry using the signal magnitude of the same OCT time series data.
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Published in final edited form as:
Opt Lett. 2017 October 01; 42(19): 3976–3979. © 2017 Optical Society of America