Highly-sensitive, label-free detection of microorganisms and viruses via interferometric reflectance imaging sensor
Date
2023-01-21
Authors
Bakhshpour-Yucel, Monireh
Gür, Sinem Diken
Seymour, Elif
Aslan, Mete
Lortlar Ünlü, Nese
Ünlü, M Selim
Version
Published version
OA Version
Citation
M. Bakhshpour-Yucel, S.D. Gür, E. Seymour, M. Aslan, N. Lortlar Ünlü, M.S. Ünlü. 2023. "Highly-Sensitive, Label-Free Detection of Microorganisms and Viruses via Interferometric Reflectance Imaging Sensor." Micromachines, Volume 14, Issue 2, pp.281-. https://doi.org/10.3390/mi14020281
Abstract
Pathogenic microorganisms and viruses can easily transfer from one host to another and cause disease in humans. The determination of these pathogens in a time- and cost-effective way is an extreme challenge for researchers. Rapid and label-free detection of pathogenic microorganisms and viruses is critical in ensuring rapid and appropriate treatment. Sensor technologies have shown considerable advancements in viral diagnostics, demonstrating their great potential for being fast and sensitive detection platforms. In this review, we present a summary of the use of an interferometric reflectance imaging sensor (IRIS) for the detection of microorganisms. We highlight low magnification modality of IRIS as an ensemble biomolecular mass measurement technique and high magnification modality for the digital detection of individual nanoparticles and viruses. We discuss the two different modalities of IRIS and their applications in the sensitive detection of microorganisms and viruses.
Description
License
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).