Hemagglutination properties of human oral veillonellae
Date
1994
DOI
Authors
Regudo, Maria Margarita C
Version
OA Version
Citation
Abstract
Many oral bacteria express adhesions that bind to ligands exposed by neuraninidase treatment of oral surfaces. Veillonellae, common isolates from subgingival dental plaque, play a critical role in plaque microbial ecology. Although previous studies have described the ability of veillonella isolates to adhere to other oral bacteria, little is known about their interactions with human cells. In the present study, we tested the ability of 14 veillonella isolates to agglutinate a variety of human and animal erythrocytes (RBCs). Variable weak hemagglutination reactions were seen with untreated human and animal RBCs. However, when the human RBCs were treated with neuramindase,strong hemagglutination reactions were observed for 7 of the 14 isolates tested. Moreover,some of these interactions with neuraninidase-treated RBCs were inhibited ty the sugars galactose and lactose and the amino acids, arginine and lysine. These data suggests that many veillonella isolates express molecules capable of recognizing carbohydrate moieties on eukaryotic cells exposed by neuraminidase treatment and may play a role in colonization of the gingival crevice by veillonellae.
Description
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Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1994 (Pediatric Dentistry).
Includes bibliographical references: (leaves 73-91).
Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1994 (Pediatric Dentistry).
Includes bibliographical references: (leaves 73-91).
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.