Electrographic seizures during low-current thalamic deep brain stimulation in mice
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Date
2024
Version
Accepted manuscript
OA Version
Citation
F.J. Flores, I. Dalla Betta, J. Tauber, D.R. Schreier, E.P. Stephen, M.A. Wilson, E.N. Brown. 2024. "Electrographic seizures during low-current thalamic deep brain stimulation in mice." Brain Stimulation, Volume 17, Issue 5, pp.975-979. https://doi.org/10.1016/j.brs.2024.08.002
Abstract
BACKGROUND: Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT). OBJECTIVES: To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice. METHODS: Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration. RESULTS: In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA. CONCLUSION: Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.
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Attribution-NonCommercial-NoDerivatives 4.0 International