Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.
Date
2016-09-14
Authors
Kärkäs, Markus D.
Porco, John A.
Stephenson, Corey R.J.
Version
OA Version
Citation
Markus D Kärkäs, John A Porco, Corey RJ Stephenson. 2016. "Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.." Chem Rev, Volume 116, Issue 17, pp. 9683 - 9747.
Abstract
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the involvement of electronically excited states, generated upon absorption of photons. This produces transient reactive intermediates and significantly alters the reactivity of a chemical compound. The input of energy provided by light thus offers a means to produce strained and unique target compounds that cannot be assembled using thermal protocols. This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds. Synthetic designs based on photochemical transformations have the potential to afford complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
Description
License
© 2016 American Chemical Society. This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes.