Immunohistochemical investigation of TGF-beta expression in posterior gingival tissue of phenytoin treated mice
Date
2015
DOI
Authors
Cho, Gyusik
Version
OA Version
Citation
Abstract
Patients undergoing phenytoin treatment may develop gingival overgrowth as
a side effect. During drug-induced gingival overgrowth (DIGO), epithelial
tissues will go through epithelial to mesenchymal transition (EMT) to become
more like cormective tissue. EMT is associated with fibrosis as well as cancer.
Objectives: The objective of this experiment is to investigate TGF-beta
expression in posterior gingival epithelial and comective tissues of phenytoin
treated mice in order to assess for a correlation between TGF-beta expression
and gingival overgrowth in mice. The overall hypothesis is that since the
gingival overgrowth does not happen extensively in the posterior gingival
tissues, TGF-beta expression may not be highly expressed in the posterior
gingival tissues. This study is a part of a larger prqiect to replicate human
Phenytoin-induced gingival overgrowth in a mouse model in order to study and ... [TRUNCATED]
Description
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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2015 (Department of Molecular and Cell Biology).
Includes bibliography: leaves 35-44.
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2015 (Department of Molecular and Cell Biology).
Includes bibliography: leaves 35-44.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.