Murder on the ovarian express: a tale of non-autonomous cell death in the Drosophila ovary
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Published version
Date
2021-06-10
Authors
Lebo, Diane Patricia Vig
McCall, Kimberly
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Published version
OA Version
Citation
D.P.V. Lebo, K. McCall. 2021. "Murder on the Ovarian Express: A Tale of Non-Autonomous Cell Death in the Drosophila Ovary." Cells, Volume 10, Issue 6, pp.1454-. https://doi.org/10.3390/cells10061454
Abstract
Throughout oogenesis, Drosophila egg chambers traverse the fine line between survival and death. After surviving the ten early and middle stages of oogenesis, egg chambers drastically change their size and structure to produce fully developed oocytes. The development of an oocyte comes at a cost, the price is the lives of the oocyte's 15 siblings, the nurse cells. These nurse cells do not die of their own accord. Their death is dependent upon their neighbors-the stretch follicle cells. Stretch follicle cells are nonprofessional phagocytes that spend the final stages of oogenesis surrounding the nurse cells and subsequently forcing the nurse cells to give up everything for the sake of the oocyte. In this review, we provide an overview of cell death in the ovary, with a focus on recent findings concerning this phagocyte-dependent non-autonomous cell death.
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).