Inhibition of immobilization bone atrophy in rats by 5-methyl 2-thiophenecarboxylic acid
Date
1971
DOI
Authors
Shay, Norbert J.
Version
OA Version
Citation
Abstract
It has previously been reported by Wells and LLoyd that 5-MTC has prolonged hypocalcemic and hypophosphatemiceffects and that it can inhibit the hypercalcemic actions of parathyroid hormone and Vitamin D. These effects of 5-MTC appear to stem from its ability to inhibit bone resorption; and the purpose of this study was to determine if the drug would affect the bone atrophy resulting from limb denervation. In young male rates, one leg was denervated by cutting femoral and sciatic nerves. Two weeks after denervation, dry weight and ash weight of the tibias/fibulas and femurs were reduced by 20%. The addition of 5-MTC (0.35%) to regular chow diet resulted in a 20-30% reduction in post-denervation atrophy and an 8-10% increase in the weight of all the leg bones. However, the addition of 5-MTC (0.50%)to the diet resulted in no reduction in post-denervation atrophy and showed no tendency to affect the weight of the bones generally. At the 0.35% level, there was no significant effect on blood calcium levels or on average growth.
Description
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1971. (Orthodontics)
References included.
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1971. (Orthodontics)
References included.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.