Differences in complement deposition, agglutination and antibody binding between pneumococcal serotypes 15B and 15C in presence of anti-capsular 15B antibodies
OA Version
Citation
Abstract
Streptococcus pneumoniae (SP) serotypes 15B and 15C are frequent causes of invasive pneumococcal disease (IPD). The principal difference between serotypes 15B and 15C is the presence of an O-acetyl group on the pentasaccharide repeating unit of 15B polysaccharide. It remains unclear if antibodies (Ab) against SP-15B cross react with SP-15C. We evaluated anti-15B Ab activation of classical complement pathway against SP 15B and 15C and found that anti-capsular 15B antibodies induce limited C4 deposition and reduced C3 intensity on SP-15C, reflecting lower classical pathway activation in contrast to high C4 and C3 deposition on SP 15B. These observations support limited cross reactivity of anti-15B sera with 15C strains of SP.
Description
2024