Development of a potent and selective HDAC8 inhibitor
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Published version
Supporting documentation
Date
2016-10-13
Authors
Ingham, Oscar J.
Paranal, Ronald M.
Smith, William B.
Escobar, Randolph A.
Yueh, Han
Snyder, Tracy
Porco, John A.
Bradner, James E.
Beeler, Aaron B.
Version
OA Version
Citation
Oscar J Ingham, Ronald M Paranal, William B Smith, Randolph A Escobar, Han Yueh, Tracy Snyder, John A Porco, James E Bradner, Aaron B Beeler. 2016. "Development of a Potent and Selective HDAC8 Inhibitor.." ACS Med Chem Lett, Volume 7, Issue 10, pp. 929 - 932.
Abstract
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
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License
© 2016 American Chemical Society