Due to intravascular multiple sequential scattering, diffuse correlation spectroscopy of tissue primarily measures relative red blood cell motion within vessels
Date
2011-07-01
Authors
Carp, Stefan A.
Roche-Labarbe, Nadàege
Franceschini, Maria Angela
Srinivasan, Vivek J.
Sakadžić, Sava
Boas, David A.
Version
Published version
OA Version
Citation
Stefan A Carp, Nadàege Roche-Labarbe, Maria-Angela Franceschini, Vivek J Srinivasan, Sava Sakadžić, David A Boas. 2011. "Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels.." Biomed Opt Express, Volume 2, Issue 7, pp. 2047 - 2054. https://doi.org/10.1364/BOE.2.002047
Abstract
We suggest that Diffuse Correlation Spectroscopy (DCS) measurements of tissue blood flow primarily probe relative red blood cell (RBC) motion, due to the occurrence of multiple sequential scattering events within blood vessels. The magnitude of RBC shear-induced diffusion is known to correlate with flow velocity, explaining previous reports of linear scaling of the DCS "blood flow index" with tissue perfusion despite the observed diffusion-like auto-correlation decay. Further, by modeling RBC mean square displacement using a formulation that captures the transition from ballistic to diffusive motion, we improve the fit to experimental data and recover effective diffusion coefficients and velocity de-correlation time scales in the range expected from previous blood rheology studies.
Description
License
© 2011 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.