The effects of tumor necrosis factor and interleukin 1 on osseous and soft tissue wound healing
OA Version
Citation
Abstract
The role of inflammatory mediators in surgical repair has
not been delineated. Tumor necrosis factor alpha (TNFa)
and interleukin-1 beta (IL-1~) are cytokines, which are
recognized as potent stimulators of the initial
inflammatory response. In our study we tested the
hypothesis that stimulation by the inflammatory cytokines
tumor necrosis factor (TNF) and interleukin-1 (IL-1) are
necessary for osseous and soft tissue wound healing. A
calvarial osteotomy, 1mm in diameter, was created in three
groups of mice: one with targeted deletions of the TNF
receptors p55 and p75, one with targeted deletions of the
IL-1 receptor type I, and one with wild-type (control)
mice. Bone healing was assessed by quantitative
histomorphometry. Because three mice died, the number of
animals in the experiment was not large enough to produce
viable statistical results. However, we observed reduced
osseous healing between the experimental groups (TNF p55-
/p75- and IL-1 -/-) and the control group at Day 14. [TRUNCATED]
Description
Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2002 (Endodontics).
Includes bibliography (leaves 63-68).
Includes bibliography (leaves 63-68).
License
This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.