A review of literature: regeneration of the dentin/cementum-to-bone interface
OA Version
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Abstract
Periodontal regeneration is one of the key concepts in the treatment of periodontitis. However, current methods have achieved only limited success in the clinical setting, with the vast majority of outcomes falling under the definition of “repair” rather than true regeneration. This review aims to investigate whether cementum, an integral part of the periodontal-tooth interface, can be regenerated via guided tissue regeneration alone, supplemented with grafts including additives, or with the adjunct of stem cell therapy in periodontitis patients. Using a PICO-formatted question, MeSH terms were generated and run through four databases (PubMed, Cochrane, Web of Science, Embase). The results were screened and selected based on inclusion and exclusion criteria, then summarized to create this narrative review. There was insufficient evidence to favor a single superior technique or material in the regeneration of cementum. The addition of Emdogain, growth factors, laser therapy, and stem cells appear to show some clinical benefit over conventional therapy in existing studies, but further higher-level studies are needed to confirm these findings.
Description
2025