Divergent total syntheses of rhodomyrtosones A and B
Files
Accepted manuscript
Date
2015-10-02
Authors
Gervais, Anais
Lazarski, Kiel E.
Porco, John A.
Version
OA Version
Citation
Anais Gervais, Kiel E Lazarski, John A Porco. 2015. "Divergent Total Syntheses of Rhodomyrtosones A and B.." J Org Chem, Volume 80, Issue 19, pp. 9584 - 9591.
Abstract
Herein, we report total syntheses of the tetramethyldihydroxanthene natural product rhodomyrtosone B and the related bis-furan β-triketone natural product rhodomyrtosone A. Nickel-(II)-catalyzed 1,4-conjugate addition of an α-alkylidene-β-dicarbonyl substrate was developed to access the congener rhodomyrtosone B, and oxygenation of the same monoalkylidene derivative followed by cyclization was employed to obtain the bis-furan natural product rhodomyrtosone A.