Production of atherosclerotic lesions in the jaws of monkeys
Date
[1966]
DOI
Authors
Doyle, John L.
Version
OA Version
Citation
Abstract
Atherosclerosis is a disease process which is present in virtually every adult in the United States today, to one degree or another. Its major complication, coronary thrombosis and occlusion, is the most severe public health problem in the Country. When we add to this the less frequent complications of cerebral thrombosis and hemorrhage, aortic aneurysm, peripheral gangrene, and infarction of visceral organs, it becomes easy to see why the process of atherosclerosis is being intently studied today from every conceivable angle in the hope that an understanding of its pathogenesis will lead to effective preventive measures.
Periodontal disease is similar to atherosclerosis in many respects. Its incidence increases with age and it is the major cause of tooth loss in adults in the United States today. However, it can usually be arrested by elimination of the local inflammatory lesion and other local measures such as oral physiotherapy and elimination of occlusal trauma.
Several investigators have attempted to show a correlation between severity of atherosclerosis based on the clinical complications of the disease, and periodontal disease. That a correlation exists would not be surprising since both diseases tend to increase in severity with age. However, one may also take the view that the correlation may be understated because many people with rather severe atherosclerosis may not exhibit clinical signs relating to the cardiovascular system as such.
The purpose of this paper will be to report the production of atherosclerotic lesions of the jaws in monkeys and to review the literature pertaining to the correlation between atherosclerosis and periodontal disease.
Description
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Thesis--Boston University, School of Graduate Dentistry, 1966.
Thesis--Boston University, School of Graduate Dentistry, 1966.
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This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.