The use of antibiotics in the treatment localized juvenile periodontics
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Abstract
Treatment studies of Localized juvenile periodontitis (LJP) have
revealed a direct relationship between the elimination of Actinobacillus
actinomycetemcomitans (A.a.) from the deep pocket epithelium, and disease
cessation. To evaluate the successful treatment outcome in LJP patients, we
compared pre and post treatment levels in A.a. in this patient population to
treatment outcome. Ten LJP patients were randomly divided into two groups,
with one group receiving antibiotic therapy (a combination of metronidazole and
amoxicillin) and the other receiving no antibiotic. Both groups received full
polymorphonuclear leukocyte (PMN) chemotaxis evaluation, microbiologic
screening, oral hygiene instruction (OHi) and full mouth scaling and root-planing
(S/RP) prior to surgical therapy. The surgical protocol included open flap
debridement without resective or regenerative therapy. Using the DNA
checkerboard method A.a. levels were measured, from samples obtained before
and after treatment. The findings demonstrate that A.a. serotype b was the
dominant strain throughout the clinical trial and all the patients n=10 (100%)
expressed depressed PMN chemotaxis at baseline and at 24-months. The sites
surgically treated yielded a mean probing depth reduction of 1.48mm (antibiotic)
and 0.66mm (non-antibiotic) respectively. The treatment groups responded well
to therapy and there was no statistical difference between both groups. The
study suggests that LJP cases respond positively to therapy and that the
judicious use of antibiotic therapy can provide improvement.
Description
Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1999 (Periodontology and Oral Biology).
Includes bibliographical references (leaves 67-78).
Includes bibliographical references (leaves 67-78).
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This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.