Ultrastructural observations in the oral tissues of normal and diabetic Chinese hamsters using horseradish peroxidase as a cytochemical tracer
Date
1976
DOI
Authors
Michaelides, Paul L.
Version
OA Version
Citation
Abstract
Diabetes Mellitus is a genetic metabolic disease traditionally characterized by a relative or an absolute lack of insulin production and by a striking predisposition to vascular disease. Non-hereditary diabetes is seen in certain forms of hyperadrenalism: acromegaly; with pheno-chromocytomas; and with acquired pancreatic disease which occurs whenever some significant portion of the pancreas and its islets is surgically removed or destroyed by disease. The hereditary form of diabetes is by far the most common, and the manifestations of this disease will be the focus of the following discussion.
Diabetes may be the most important metabolic disturbance affecting human cell physiology and biochemistry in the United States today due to its high incidence. As a reasonable estimate, approximately 2 per cent of Americans have diabetes but only about half of them have been diagnosed (Robbins, 1974). It is further estimated that from projections of known diabetics and their family trees that perhaps 5 per cent of the American population are potentially diabetic because they harbor the genetic trait (Sharkey, 1971). Since the disease may appear at any time its prevalence is potentially higher in each progressive decade of life until in the eighth decade its incidence is greater than 10 per cent. Thus, diabetes and its influence on the tissues of the body is a ubiquitous problem to all practitioners of the health sciences.
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Description
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Thesis (M.Sc.D)--Boston University School of Graduate Dentistry, Dept. of Periodontology, 1976.
Includes bibliography.
Thesis (M.Sc.D)--Boston University School of Graduate Dentistry, Dept. of Periodontology, 1976.
Includes bibliography.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.