A study of the enzymatic mechanism responsible for the hepatic and renal excretion of certain carboxylic and sulfonic acids
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Abstract
The renal tubules and the liver are capable of excreting a variety of organic acids against high concentration gradients. The hepatic and renal groups of excreted compounds are not identical, though they are chemically very closely related. Some o£ the compounds are excreted by both organs. The substances excreted by either organ include carboxylic acids, sulfonic acids and sulfate esters. Some of the compounds under consideration are: Substances used to test for kidney or liver excretory function: p-aminohippuric acid (PAH), phenol red, bromsulfalein, Rose Bengal. Certain conjugates: hippuric acid, glycocholic acid, taurocholic acid, bilirubin diglucuronide. Urographic and cholecystographic agents: Diodrast, Skiodan, Cholografin, Priodax.
The intimate manner in which the compounds excreted by either organ compete with each other for excretion has indicated to many workers that they are all excreted by the same mechanism. The close resemblance of hepatic and renal groups indicates the probability that the same basic excretion mechanism is involved in either organ, differing only in details of enzyme specificity. The high concentration gradients attainable suggest that high-energy intermediates are involved in the excretion of these acids. [TRUNCATED]
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Thesis (Ph.D.)--Boston University
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