Isolation and characterization of gluten degrading enzymes derived from Rothia species
Date
2012
DOI
Authors
Blumenkranz, Gabriel
Blumenkranz Sanchez, Gabriel
Version
OA Version
Citation
Abstract
Celiac disease (CD) is an inflammatory enteropathy of the small intestine, which affects
certain genetically predisposed individuals. The disease is triggered upon ingestion of
wheat gluten and similar proteins found in other cereals such as barley and rye. Once
diagnosed, celiac patients must adhere strictly to a gluten free diet, since no true therapy is
currently available. The gliadin fractions of gluten proteins contain multiple T-cell epitopes
within their primary structure. These domains are responsible for the high immunogenicity
presented by the gliadin fractions upon ingestion. The human-encoded enzymatic arsenal
lacks cleavage capacities towards these peptides. For this reason, the use of external
gliadin-degrading proteases has been proposed as a therapeutic alternative for the
treatment of CD. [TRUNCATED]
Description
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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2012 (Department of Periodontology and Oral Biology).
Includes bibliography: leaves 58-65.
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2012 (Department of Periodontology and Oral Biology).
Includes bibliography: leaves 58-65.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.