The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjögren-like disease
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Abstract
Sjogren's syndrome (SS) is a chronic, multisystem inflammatory disorder of
multifactorial etiology resulting in loss of secretory function in the exocrine glands
including salivary and lacrimal. Even though the pathophysiology progression of SS has
been subject to great amount of research, the roles of different mechanisms remain
inconclusive. The main dogma is that immune system pathology drives SS; however,
there is no straightforward pathogenesis theory as there are multiple autoantibodies and
changing proportions of different T-cell subsets with the progression of the disease along
with many other different contributors. Interestingly, increasing evidence points to
structural defects, including defective E-cadherin adhesion, to be involved in the etiology
of SS. Recently, the Hippo signaling pathway has emerged as one of the main pathways
regulating size of the organs and proliferation/ differentiation of cells, in part via
interaction with E-cadherin junctions. Despite this, the role of Hippo signaling in the ... [TRUNCATED]
Description
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Endodontics).
Includes bibliographic references: leaves 41-49.
Includes bibliographic references: leaves 41-49.
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