Healing of an induced wound in the marrow of the iliac crest of dogs: a histologic investigation
Date
1971
DOI
Authors
Butler, Lawrence M.
Version
OA Version
Citation
Abstract
The purpose of this study. was to describe the bone-related aspects of healing hemopoietic marrow of dogs in hopes
of determining at what time re-entry into the area would yield
the best donor tissue for marrow autografts. Six adult,
clinically healthy, mongrel dogs were used. A wound was
created with a Westerman-Jensen bone marrow biopsy needle in
the ilium of the animal. The period of the study was from one
week to four months. Relative values of various marrow components
were assessed on an arbitrary basis.
The results showed a dramatic rise in all the marrow
elements within the wound area. The white blood cells remained
at a consistently high level for the first month of the study.
These then declined but were still higher than normal at the
end of the period evaluated. The osteoblasts were at a much
higher level than normal for the first two weeks of the study,
and then declined slightly. They too remained elevated at
the end of four months.
The osteoclasts were also greatly increased at one week,
however, their numbers dropped dramatically at two weeks, and
were normal by one month. They stayed at this level for the
duration of the study.
Description
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Thesis (M.S.D.)--Boston University, School of Graduate Dentistry, 1971 (Periodontology).
Thesis (M.S.D.)--Boston University, School of Graduate Dentistry, 1971 (Periodontology).
License
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