Pre-emptive analgesic effects of a selective cox-2 inhibitor, rofecoxib
Date
2004
DOI
Authors
Rodriguez, Carolina
Version
OA Version
Citation
Abstract
Preemptive administration of nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduces the intensity and duration of postoperative pain by attenuating the inflammatory response thereby reducing peripheral sensitization and its effect on nociceptive processing, including induction and maintenance of central sensitization. Selective COX-2 inhibitors provide the analgesic and anti-inflammatory effects of conventional NSAIDs with an improved safety profile by sparing COX- 1 functions.
This study compared the therapeutic potential of preemptive administration of rofecoxib 50 mg, ibuprofen 400 mg, and placebo using the oral surgery model. Subjects received one of three treatments. The preoperative dose was given 90 minutes before oral surgery and a second dose was given at 24 hours. The sum of the pain VAS and four point category scale over the four hour observation period and at 24 and 48 hours demonstrated significant pain reduction in the ibuprofen group and the rofecoxib group when compared to placebo. The ibuprofen group showed significantly greater pain reduction when compared to placebo and rofecoxib. Fewer subjects remedicated in either of the drug treatment groups. The incidence of adverse effects and local complications did not differ across groups. These data suggest that pre-emptive administration of a selective COX-2 inhibitor, rofecoxib does not differ significantly from a traditional non-selective COX inhibitor, ibuprofen. Both resulted in significantly greater reduction in pain intensity in the immediate postoperative period, but not at 24 or 48 hours. Both active drug treatment groups remedicated significantly less than the placebo group throughout the entire duration of the study.
Description
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Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004.
Includes bibliographical references (leaves 95-116).
Thesis (M.S.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2004.
Includes bibliographical references (leaves 95-116).